![]() The JIP proteins function by aggregating components of a MAP kinase module (including MLK, MKK7, and JNK) and facilitate signal transmission by the protein kinase cascade. The scaffold proteins JIP1 and JIP2 interact to form oligomeric complexes that accumulate in peripheral cytoplasmic projections extended at the cell surface. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates signaling by the mixed-lineage kinase (MLK)->MAP kinase kinase 7 (MKK7)->JNK pathway. ![]() This signaling mechanism may be coordinated by the interaction of components of the protein kinase cascade with scaffold proteins. The JIP proteins function by aggregating components of a MAP kinase module (including MLK, MKK7, and JNK) and facilitate signal transmission by the protein kinase cascade.ĪB - Activation of the c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is mediated by a protein kinase cascade. The scaffold proteins JIP1 and JIP2 interact to form oligomeric complexes that accumulate in peripheral cytoplasmic projections extended at the cell surface. Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an. N2 - Activation of the c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is mediated by a protein kinase cascade. This review discusses similarities and differences in scaffolding proteins and mechanisms in yeast, flies, worms and mammals.T1 - The JIP group of mitogen-activated protein kinase scaffold proteins In many, if not all cases, the three-kinase cascade, conveniently referred to as a MAP kinase module, is organized on scaffolds with a variety of forms and functions. They are activated within protein kinase cascades consisting of at least three kinases acting in series. This review discusses similarities and differences in scaffolding proteins and mechanisms in yeast, flies, worms and mammals.ĪB - MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. the opposing regulation of protein kinaseA (PKA) in direct and indirect. In many, if not all cases, the three-kinase cascade, conveniently referred to as a MAP kinase module, is organized on scaffolds with a variety of forms and functions. and iSPNs) is regulated by two distinct networks of GPCR signaling cascades. N2 - MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. MK has been supported by a fellowship from the Perot Family Foundation. Work from the authors’ laboratory was supported by grants from the National Institutes of Health and the Welch Foundation (l1243). The authors thank Elliott Ross and members of the Cobb laboratory especially Lori Christerson and Gray Pearson for critical suggestions and comments about the manuscript, and Lavette James for administrative assistance. T1 - Scaffolding and protein interactions in MAP kinase modules
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